One mutation. Three blood cancers. Endless consequences — understand JAK2 in 60 seconds!
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One mutation. Three blood cancers. Endless consequences — understand JAK2 in 60 seconds!
🧬 What is JAK2 Mutation? • JAK2 = Janus Kinase 2, a tyrosine kinase • Key part of the JAK–STAT signaling pathway • Controls production of RBCs, WBCs, and platelets • Mutation → pathway stays ON all the time → uncontrolled blood cell growth ⸻ 🔬 Common JAK2 Mutations • JAK2 V617F • Most common mutation • Seen in ...
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