Myc - Wikipedia
The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this …
The MYC oncogene — the grand orchestrator of cancer growth and …
MYC has two paralogues: MYCL and MYCN. The initially held view was that MYC is ubiquitously involved in human cancers (both haematological and solid), whereas L-MYC is associated with small …
MYC Gene - GeneCards | MYC Protein | MYC Antibody
Jan 15, 2026 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double …
High‑MYC Tumors Evade the Immune System by Clearing R‑Loop …
15 hours ago · MYC‑driven tumors silence innate immune alarms by clearing R‑loop–derived signals, exposing a new therapeutic angle for targeting MYC without broad inhibition.
MYC in cancer: from undruggable target to clinical trials
Feb 19, 2025 · This Review provides an overview of the various strategies to inhibit MYC, focusing on the most recently described inhibitors and those that have reached clinical trials.
MYC: there is more to it than cancer - Frontiers
Mar 6, 2024 · MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular …
MYC: there is more to it than cancer - PMC
MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular proliferation, …
MYC function and regulation in physiological perspective
Oct 24, 2023 · MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression. MYC levels are tightly regulated, and deregulation of MYC has been associated with …
The effects of MYC on tumor immunity and immunotherapy
Mar 25, 2023 · The abnormal expression of MYC is one of the most common carcinogenic events in human cancer. MYC modulates immune effector cells and immune regulatory factors in the tumor …
MYC, Metabolism, and Cancer - PMC
The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective …