Metabolic reprogramming in the tumor microenvironment shapes immune function and therapy resistance, offering insights into ...

This repository provides a comprehensive and reproducible suite of R scripts for analyzing Spatial Transcriptomics (ST) data. It compares the performance and results of Seurat and Giotto, and ...

Background: Dysregulated fibroblasts and macrophages have been implicated in vascular remodeling in pulmonary arterial hypertension (PAH). Macrophages are known to modulate fibroblast activity in ...

Drug discovery is becoming more personalized, and the methods used to generate therapeutic insights are advancing alongside it. Spatial biology tools let researchers interrogate tissue function, cell ...

Thanks for the amazing tool! I was wondering If you were planning to add a module for spatial transcriptomics data as most packages have difficulties for conversion. I leave here a snippet of code I ...

The liver is a highly multifunctional organ that can perform many metabolic and immunological functions due to a highly complex spatially organised microarchitecture that is disturbed in many liver ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This study employs spatial transcriptomics to explore the ...

Challenges and Prospects. Challenges and prospects faced by spatial transcriptomics itself and its application to the musculoskeletal system. AI Artificial intelligence, FFPE Formalin fixed and ...

3 Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology Research Program, Oklahoma City, United States of America 4 University of Oklahoma Health Sciences Center, Department of ...

Background: Cardiac sarcomas, such as leiomyosarcoma (LMS), synovial sarcoma (SS), and undifferentiated pleomorphic sarcoma (UPS), lack sufficient diagnostic markers for early diagnosis and tailored ...