ABSTRACT: In this paper, we study a three-dimensional target-mediated drug disposition model consisted of the drugs (ligands), targets (receptors) and drug-target (ligand-receptor) complexes. In this ...

Discover how to build a homemade rubber band-powered paper airplane in this easy and engaging tutorial. We’ll guide you step-by-step as you craft the frame with skewers, add aerodynamic paper wings, ...

In the UK, there was a case where TGN1412, an immunotherapy under development, triggered a cytokine storm within hours of administration to humans, leading to multiple organ failure. Another example, ...

The Centers for Medicare & Medicaid Services (CMS) late last week announced the creation of the GENErating cost Reductions for US (GENEROUS) Medicaid Model, which will utilize most-favored nation ...

The GENEROUS Model aims to reduce Medicaid drug costs by aligning prices with international standards, launching in 2026. It builds on existing programs like the Medicaid Drug Rebate Program and the ...

Carrum Health launched a substance use disorder treatment program for employers a year ago and has now expanded it to include cannabis, cocaine and methamphetamine as employer demand surges. This ...

Cigna Group is launching a new rebate-free pharmacy benefit model which aims to bring down drug costs and simplify the payment process. Through its subsidiary Evernorth Health Services, a health ...

This process is costly, time-consuming, and has a low success rate. KAIST researchers have developed an AI model that, using only information about the target protein, can design optimal drug ...

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs. In recent years, models like ...

Model Context Protocol, or MCP, is arguably the most powerful innovation in AI integration to date, but sadly, its purpose and potential are largely misunderstood. So what's the best way to really ...