C&EN

Structure–Function Activity Relationships of Cariprazine Analogues with Distinct G Protein versus β-Arrestin Activities at the Dopamine D3 Receptor

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse ─ Intramural Research Program, National Institutes of Health, 333 Cassell Drive, ...
eLife

Learning sequence-function relationships with scalable, interpretable Gaussian processes

This important work introduces a family of interpretable Gaussian process models that allows us to learn and model sequence-function relationships in biomolecules. These models are applied to three ...
Foreign Affairs

Structure Trumps Agency in the U.S.-China Relationship

In the United States, bipartisan consensus is painfully hard to achieve—except on the issue of China. Even as American political polarization has intensified over the last eight years, both ...
The New York Times

The Best Relationship Advice We’ve Heard So Far This Year

These expert tips on how to argue, communicate and grow closer with the people you love could make for stronger bonds. Credit...Jackson Gibbs Supported by By Catherine Pearson and Jancee Dunn Building ...
IEEE

Multiscale Motif-Aware Relation Graph Structure for Drug-Target Binding Affinity Prediction

Abstract: Exploring drug-target binding affinity (DTA) is essential for drug discovery. Numerous works rely on the one-dimensional SMILES representation of drugs for predicting drug-target affinity, ...
ahajournals.org

Mitochondrial Structure and Function in Human Heart Failure

Despite clinical and scientific advancements, heart failure is the major cause of morbidity and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the development and ...
C&EN

Review on the Structure–Property Relationship of Lignocellulosic Materials Measured by Atomic Force Microscopy

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Trees and plants in general have evolved to a system of optimal ...
Frontiers

Editorial: Structure-function relationship of enzymes through a chemical lens

1 Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN, United States 2 Department of Chemistry, East Carolina University, Greenville, NC, United States With methods ranging ...
IEEE

Structure-Function Coupling in the Human Connectome with Hypergraph Neural Networks

Abstract: Structure-function coupling in the human connectome is a critical research area in neuroscience. Understanding the relationship between the brain’s anatomical architecture and its functional ...
Scientific Research Publishing

Radu, P., Zurzu, M., Paic, V., Bratucu, M., Garofil, D., Tigora, A.,

ABSTRACT: The decreasing of hazard ratio for cancer incidence (HRCVD) in the range of twenty native tissues (lung, liver, brain, hematologic, neuroendocrine renal, pancreas, lymphoid, bladder, colon, ...
Neuroscience News

Brain Networks Vary in Structure-Function Link

Summary: Researchers reveal that the relationship between brain structure and function varies significantly across different brain regions. In primary sensory and motor regions, neuron wiring strongly ...