Abstract: Co-optimizing mRNA sequences for both codon optimality and secondary structure is crucial for producing stable and efficacious mRNA therapeutics. Codon optimization, which adjusts nucleotide ...
An illustration of E. coli. Scientists have been racing to shrink the genetic code of this bacterium. Kateryna Kon / Science Photo Library via Getty Images The DNA of nearly all life on Earth is made ...
The DNA of nearly all life on Earth contains many redundancies, and scientists have long wondered whether these redundancies served a purpose or if they were just leftovers from evolutionary processes ...
We have gone further than ever before in creating life that is unlike anything that has evolved naturally. The genome of an Escherichia coli bacterium has been redesigned on a computer to use just 57 ...
In a giant feat of genetic engineering, scientists have created bacteria that make proteins in a radically different way than all natural species do. By Carl Zimmer At the heart of all life is a code.
Liquid culture flasks of bacteria grown in yellow broth covered with tinfoil on a shaker. Bacterial strains needed to be tested every step of the way to create the highly compressed genome. Credit: ...
Abstract: The concept of codon optimization is one that has recently been introduced to overcome the potential functional problems of DNA introduced into foreign hosts. We present a dynamic ...
Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...
GenScript, a global leader in life science research tools and services support, has expanded its mRNA synthesis and formulation capabilities with the launch of a GMP-like mRNA manufacturing service, ...
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