This study presents SynaptoGen, a differentiable extension of connectome models that links gene expression, protein-protein interaction probabilities, synaptic multiplicity, and synaptic weights, and ...

Abstract: Co-optimizing mRNA sequences for both codon optimality and secondary structure is crucial for producing stable and efficacious mRNA therapeutics. Codon optimization, which adjusts nucleotide ...

[Andrew Greenberg] has some specific ideas for how open-source hardware hackers could do a better job with their KiCad schematics. In his work with students at Portland State University, [Andrew] ...

Journal Editorial Report: The week's best and worst from Allysia Finley, Mene Ukueberuwa and Kim Strassel. I am a patriotic American and a proud Jew. I consider it my civic duty to fight antisemitism ...

A 163-page PDF of the iPhone 16e electrical schematics was briefly made public by the FCC, despite Apple’s express request to keep them confidential. Here’s what they showed. The filing included a ...

The Federal Communications Commission has seemingly leaked schematics for the iPhone 16e, despite Apple specifically requesting for them to be confidentially held. For complex communications hardware ...

We often think that if a piece of software had the level of documentation you usually see for hardware, you wouldn’t think much of it. Sure, there are exceptions. Some hardware is beautifully ...

An illustration of E. coli. Scientists have been racing to shrink the genetic code of this bacterium. Kateryna Kon / Science Photo Library via Getty Images The DNA of nearly all life on Earth is made ...

The DNA of nearly all life on Earth contains many redundancies, and scientists have long wondered whether these redundancies served a purpose or if they were just leftovers from evolutionary processes ...

We have gone further than ever before in creating life that is unlike anything that has evolved naturally. The genome of an Escherichia coli bacterium has been redesigned on a computer to use just 57 ...

In a giant feat of genetic engineering, scientists have created bacteria that make proteins in a radically different way than all natural species do. By Carl Zimmer At the heart of all life is a code.