In the PARAMEDIC-3 trial conducted in the U.K., the 30-day survival rate was 4.5% when the first attempt at access was intraosseous and 5.1% with the intravenous-first strategy (adjusted OR 0.94, 95% ...
For patients experiencing out-of-hospital cardiac arrest and needing drugs, a strategy of paramedics attempting intraosseous access first does not improve survival. A pragmatic, randomised PARAMEDIC-3 ...
In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug ...
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