Treatment of Relapsed Wilms’ Tumor With High-Dose Therapy and Autologous Hematopoietic Stem-Cell Rescue: The Experience at Children’s Memorial Hospital Interleukin-12 (IL-12) and interferon alfa-2b ...

Purpose: To maintain interferon gamma (IFNγ) induction by recombinant human interleukin-12 (rhIL-12) and enhance its activity against melanoma and renal cell cancer, a regimen of twice-weekly ...

Interleukin-12 (IL-12) is a pleiotropic cytokine designated as a cytotoxic lymphocyte maturation factor and NK cell stimulator that interconnects innate and adaptive immunity. Studies in animal models ...

Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear away cellular debris—including the plaques typical of Alzheimer's disease.

During the COVID-19 pandemic, mRNA vaccines came to the rescue, developed in record time and saving lives worldwide. Researchers in the Precision Vaccines Program at Boston Children's Hospital have ...