Cellular death within the infarcted core occurs rapidly due to energy depletion, resulting in the release of DAMPs such as HMGB1, ATP, and HSPs. These DAMPs engage pattern recognition receptors, ...

In response to alcohol, various cellular and molecular changes occur in the liver, contributing to hepatic steatosis, inflammation and fibrosis. Hepatocytes exhibit increased production of reactive ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

The inflammasome, a multiprotein complex, plays a crucial role in the field of innate immunity. It is activated by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular ...