The inability of cells to eliminate damaged proteins and organelles following the blockage of a coronary artery and its subsequent re-opening with angioplasty or medications - a sequence known as ...

BAG3 is a multifunctional co‐chaperone that plays a central role in maintaining protein quality control by regulating the activity of heat shock proteins, particularly Hsp70. Its versatile ...

BAG3 DCM is a devastating monogenic heart disease affecting more than 70,000 patients in the U.S., Europe, and U.K., with almost 25% of patients requiring a heart transplant AFTX-201 is a potential ...

BAG3-associated dilated cardiomyopathy is a rare, inherited heart condition caused by mutations in the BAG3 gene, leading to early-onset, progressive heart failure due to impaired cardiac function, ...

The BAG3 gene, or Bcl2-associated athanogene 3, encodes for a protein that is critical to the normal structure and function of heart cells. Patients with BAG3 DCM have a mutation in the BAG3 gene and ...

BAG3 DCM is a serious, inherited heart condition with a high mortality and a significant unmet medical need. The disease affects more than 70,000 patients in the U.S., Europe, and U.K. regions alone.

Rocket Pharmaceuticals RCKT announced that the FDA has cleared its investigational new drug (IND) application seeking to begin clinical studies on its first-in-class gene therapy candidate, RP-A701.

Researchers found that traumatic brain injury increases synaptic dysfunction and cognitive impairments linked to developing Alzheimer's disease. Study: Neuronal BAG3 attenuates tau ...